Drake, who has skipped his fair share of awards shows in recent years, was the big winner with four awards and debuted a new commercial for Apple Music.

"For our genre, I just like to keep things excited and keep making music. Shout out to everybody that's trying to do the same thing," said Drake, who broke Michael Jackson's record for most AMA nominations after scoring 13 nominations.

Bieber, who performed from his tour in Zurich, Switzerland, also won four awards.

Gomez, who lost artist of the year to Ariana Grande but won favorite female artist — pop/rock, gave a heartfelt speech onstage that earned a loud applause from the audience at the Microsoft Theater in Los Angeles.

"I think it's safe to say that most of you know a lot of my life whether I liked it or not, and I had to stop, 'cause I had everything, and I was absolutely broken inside. And I kept it all together to where I never let you down. But I kept it too much together where I let myself down," she said.

"I don't want to see your bodies on Instagram. I want to see what's in here," Gomez said, pointing to her heart. "And I have to say thank you so much to my fans because you guys are so damn loyal, and I don't know what I did to deserve you. If you are broke, you don't have to stay broken."

Grande was shaking onstage as she collected artist of the year at the fan-voted show on ABC, beating Adele, Rihanna, Carrie Underwood and Bieber. "With or without this, I love you from the bottom of my heart," she said to her fans.

Green Day was one of many big-named acts promoting new albums at the AMAs, including Bruno Mars, the Weeknd, Lady Gaga, Sting, John Legend and The Chainsmokers. But Green Day got political during their performance of "Bang Bang" as band leader Billie Joe Armstrong sang "No KKK, no fascist USA, no Trump" during the show.

The show's hosts — former "Saturday Night Live" comic Jay Pharaoh and model Gigi Hadid — also mentioned the Trump family when telling jokes: After Pharaoh impersonated Jay Z, Hadid acted like Melania Trump.

"I love my husband, President Barack Obama, and our children, Sasha and Malia," she said, scrunching up her face.

Strumming guitars while singing was one of the night's themes: One Direction's Niall Horan slowed things down for his acoustic-folk solo single, "This Town": James Bay sang his smoky single, "Let It Go"; and Shawn Mendes performed his hit "Treat You Better" and switched to piano for the aching "Mercy."

But the best singer-guitarist was Gaga, who beautifully belted the lyrics to her latest single, "Million Reasons." She earned a rousing applause from the audience.

Sting also impressed, who performed "Message In a Bottle," ''Every Breathe You Take" and his new single, "I Can't Stop Thinking About You." He received the American Music Award of Merit, which was presented to him by Robert Downey Jr.

"American music lit the musical spark in my young mind," the English singer said after his performance. "My musical soul is all American!"

Other highlights included double winners twenty one pilots and Mars, who kicked off the AMAs with his groovy hit, "24K Magic," backed by his band who matched his slick, upbeat dance moves.

Grande and Nicki Minaj gave a steamy during their performance of the reggae-tinged "Side to Side": Grande's background dancers danced closely on her, and one male dancer even pulled up her skirt, while Minaj, who rapped from a chair, spread her legs widely.

Other performers include Maroon 5 with Kendrick Lamar and DJ Khaled with Minaj, Future, Rick Ross and August Alsina.

Prince's 1984 "Purple Rain" album, which gained new attention after his death in April, won top soundtrack. His sister, Tyka Nelson, collected his trophy onstage and cried as she spoke to the audience.

"We'll keep this for you at Paisley Park until we see you again," she said weeping and naming her siblings. "This is for you."

Other winners include Fifth Harmony, Tim McGraw, the Chainsmokers and Florida Georgia Line.

Zayn, who has won a handful of AMAs with his One Direction bandmates, took home new artist of the year.

"Wow. This one just has my name on it, right?" he said. "This has been a crazy year ... I didn't expect anyone to vote for me, so thank you for voting for me."