MELBOURNE:Rafael Nadal set up a blockbuster Australian Open quarter-final with Andy Murray on Sunday and Justine Henin’s comeback stayed on track, but there was misery for Dinara Safina who pulled out injured.

On a day of upsets, the tournament ended for US Open champion Juan Martin del Potro and French Open champion Svetlana Kuznetsova. Second seed Safina limped out with a back problem during her fourth round clash with unseeded countrywoman Maria Kirilenko. She was trailing 4-5 and 30-40 when she walked towards the umpire and indicated her night was over.

Zheng Jie, meanwhile, rewrote the history books by becoming the first Chinese player to reach the last eight in Melbourne and will now play Kirilenko. Spain’s second seeded Nadal was put to the test by big-serving Croat Ivo Karlovic, who slammed down 28 aces, before he muted the challenge 6-4, 4-6, 6-4, 6-4.

It ensured an enticing last eight showdown with in-form fifth seed Murray after the Scot tamed another big-server, American John Isner, 7-6 (7/4), 6-3, 6-2. Murray will be competing in his first Australian quarter-final and is the first Briton since John Lloyd in 1985 to get this far. He showcased his exciting strokeplay against Isner and has yet to drop a set. The pair have played each other nine times with Nadal winning seven.

Henin’s successful return to tennis after an 18-month retirement continued full steam when the seven-time Grand Slam champion beat fellow Belgian and world No 16 Yanina Wickmayer 7-6 (7/3), 1-6, 6-3. Henin is at her first Grand Slam since the Australian Open in 2008 after being handed a wildcard by organisers.

Her victory matched the best performance by a wildcard here in the Open Era — Martina Hingis in 2006 and Jelena Dokic in 2009 also made the quarters — and earned her a crack at Russian Nadia Petrova for a place in the semi-finals. Petrova, the 19th seed, made the last eight by beating third seed Kuznetsova, continuing her giantkilling ways having already ousted Kim Clijsters. She won 6-3, 3-6, 6-1.

Zheng’s achievement was impressive, with the unseeded 26-year-old upsetting Ukrainian 31st seed Alona Bondarenko 7-6 (7/5), 6-4 as she and Li Na, who plays her fourth round match on Monday, continue to fly the flag for China. Zheng proved to be marginally steadier than the Ukrainian in a match where both women struggled to hold their serves.

Argentina’s del Potro crashed out of contention in a five-set epic with 14th seed Marin Cilic. The Croatian outlasted an exhausted del Potro 5-7, 6-4, 7-5, 5-7, 6-3 to earn himself a quarter-final against American seventh seed Andy Roddick, who battled back to beat former finalist Fernando Gonzalez of Chile 6-3, 3-6, 4-6, 7-5, 6-2.