Manager Arsene Wenger has urged Arsenal to "put things right" when they take on Southampton on Tuesday by avenging the 4-0 loss they suffered at St Mary's Stadium on Boxing Day.

The Gunners' hopes for a win have been boosted by the return of forward Alexis Sanchez, who could make his first Premier League start in two months after marking his comeback from a hamstring injury by scoring in the FA Cup on Saturday.

"They (Southampton) gave us a tough game last time and we have to put that right," Wenger told reporters at his pre-match news conference.

"The message (this time) is that we play at home and we want to put a strong performance in because the strength we show at home now in the remaining games can be decisive."

Arsenal, who are third in the Premier League and through to the fifth round of the FA Cup, face Barcelona in the knockout stages of the Champions League, and Wenger said it would take something "exceptional" for his team to keep fighting on three fronts.

"It is difficult to compete on three fronts. Exceptionally, it can happen," he said.

"It is (possible) because some clubs have done it. Bayern (Munich) have done it. But you need not to have any bad injuries and to have a basis of a team who can repeat performances."