Jamie McGoldrick, a UN official in charge of humanitarian efforts in the country, said more than 525 were injured.

The death toll was 82, according to Ghazi Ismail, the administration's acting health minister. The reason for the discrepancy in numbers was not immediately clear.

Ismail said the air strike occurred in the southern part of the city, where a wake was taking place for the father of the administration's interior minister, Jalal al-Roweishan, who had died of natural causes on Friday.

The death toll was one of the largest in any single incident since the Saudi-led alliance began military operations to try to restore President Abd-Rabbu Mansour Hadi to power following his ousting by the Iran-aligned Houthis in March 2015.

"The Saudi aggression committed a major crime today, by attacking a mourning hall for the al-Roweishan family, targeting residents in the hall," Ismail told a news conference in Sanaa.

In a strongly worded rebuke, the White House said it may consider cutting its support to the Saudi-led military campaign.

"US security cooperation with Saudi Arabia is not a blank check," said US National Security Council spokesman Ned Price in a statement. "In light of this and other recent incidents, we have initiated an immediate review of our already significantly reduced support to the Saudi-led coalition and are prepared to adjust our support so as to better align with US principles, values and interests, including achieving an immediate and durable end to Yemen's tragic conflict."

Sources in the Saudi-led coalition said there was no Arab coalition air role in the strike.

"Absolutely no such operation took place at that target," one of the sources said, citing what he described as confirmation from the coalition air force command.

"The coalition is aware of such reports and is certain that it is possible that other causes of bombing are to be considered. The coalition has in the past avoided such gatherings and (they have) never been a subject of targets."

The Saudi-led coalition has been providing air support for Hadi's forces in a civil war that has killed more than 10,000 people since March 2015 and displaced more than three million.

Fighting has intensified since August when UN-sponsored peace talks in Kuwait ended without an agreement.

Iran, Saudi Arabia's main regional rival, described the attack as “a horrific and inhuman crime”, and called for the resumption of peace talks among all Yemeni parties.

“To resolve the crisis in Yemen there is no solution but the end of aggression by the brutish Saudi rulers and start of new round of talks that includes all Yemeni sides,” Iran's Foreign Ministry spokesman, Bahram Qasemi was quoted as saying by Tasnim news agency.

SCENE OF CARNAGE

Residents said aircraft fired two missiles at the hall, where hundreds of mourners had gathered to offer condolences.

One missile tore through the building, setting it on fire and sending a large plume of smoke above the area. The other landed nearby.

Witnesses described a scene of carnage, with charred or mutilated bodies strewn around. Ambulances raced to carry the wounded to hospitals, which sent out urgent appeals for blood.

A spokesman for Yemen's Houthi group condemned the strike as an act of savagery.

"The aggression continues to shed blood in an uncommon savagery and with international collusion that reaches the level of direct participation," the Houthi-run Saba news agency quoted the group's spokesman, Mohammed Abdul-Salam, as saying in a statement.

At least two local officials were among the dead. It was not immediately clear if Roweishan was in the hall when the strike happened.

Roweishan had sided with the Iran-aligned Houthi movement when President Abd-Rabbu Mansour Hadi fled Yemen after the Houthis advanced on his headquarters in the southern port city of Aden in March 2015.

The Saudi-led coalition had been blamed for several attacks on medical centers, including some run by international aid group Medecins Sans Frontieres (MSF), schools, factories and homes in the past 18 months that has killed scores of civilians.

In August, MSF said it was evacuating its staff from six hospitals in northern Yemen after a coalition air strike hit a health facility operated by the group killing 19 people.

The coalition, which says it does not target civilians, has expressed deep regret over the decision and said it was trying to set up "urgent meetings" with the medical aid group.