JERUSALEM: The Israeli military said it struck dozens of Iranian targets in Syria on Wednesday, carrying out a "wide-scale" strike in response to rocket fire on the Israeli-controlled Golan Heights the day before. Syrian state media reported that two civilians were killed.

The military said its fighter jets hit multiple targets belonging to Iran's elite Quds force, including surface-to-air missiles, weapons warehouses and military bases. After the Syrian military fired an air defence missile, the Israeli military said a number of Syrian aerial defence batteries were also destroyed.

Syria's SANA news agency said the two people were killed by shrapnel when an Israeli missile hit a house in the town of Saasaa, southwest of Damascus.

The report also said several others were wounded in the airstrikes near the capital, Damascus, including a girl in a residential building in the suburb of Qudsaya, west of the Syrian capital. It claimed that Syrian air defences destroyed most of the Israeli missiles before they reached their targets.

The strikes further burst into the open what's been a long shadow war between Israel and its archenemy Iran. The two foes have increasingly clashed over what Israel says is Iran's deeper presence along its borders.

"Yesterday's Iranian attack towards Israel is further clear proof of the purpose of the Iranian entrenchment in Syria, which threatens Israeli security, regional stability and the Syrian regime," the military said in a statement, adding that it would "continue operating firmly and resolutely" against Iran in Syria.

Israel intercepted the four rockets on the Golan Heights on Tuesday, which came amid heightened tensions between Israel and Iranian proxies along its borders. Israeli Prime Minister Benjamin Netanyahu has issued a series of warnings recently about Iranian aggression throughout the Middle East and has vowed to respond firmly.

"I made it clear: whoever harms us, we will harm them. That's what we did tonight," he said early Wednesday. "We will continue to aggressively protect Israel's security."

Israel's new hard-line defence minister, Naftali Bennett, issued an equally firm statement.

"The rules have changed: whoever fires on Israel during the day will not sleep at night," he said. "Our message to the leaders of Iran is simple: you are no longer immune. Any place you dispatch your tentacles, we will chop them off."

The rare rocket fire comes a week after an Israeli airstrike against a top Palestinian militant based in Syria. Akram al-Ajouri, a member of the leadership of the militant Islamic Jihad group who is living in exile, survived the attack but his son and granddaughter were killed.

Israel frequently strikes Iranian interests in Syria. But last week's airstrike appeared to be a rare assassination attempt of a Palestinian militant in the Syrian capital. It came the same day as another Israeli airstrike killed a senior Islamic Jihad commander in Gaza, settling off the fiercest round of fighting there in years.

Iran has forces based in Syria, Israel's northern neighbour, and supports Hezbollah militants in Lebanon. In Gaza, it supplies Islamic Jihad with cash, weapons and expertise.

Netanyahu also has claimed Iran is using Iraq and far-off Yemen, where Tehran supports Shiite Houthi rebels at war with a Saudi-led coalition backing the government, to plan attacks against Israel. Hamas also receives some support from Iran.