Paris, June 2:

Two-time Grand Slam champion Amelie Mauresmo was upset in the third round of the French Open, losing to 25th seeded Lucie Safarova 6-3, 7-6 (3).

The fifth-seeded Mauresmo, who won Wimbledon and the Australian Open in 2006, led 3-0 in each set. But she double-faulted for the eighth time to fall behind 2-0 in the tiebreaker, and a long backhand gave Safarova three match points. Safarova won when Mauresmo returned her serve into the net.

At 4-3 in the first set, tournament doctor Bernard Montalvan came on center court to treat Mauresmo, who then left for several minutes to take a medical break. When she returned, the top of her right thigh was wrapped.

Safarova lost in the first round at Roland Garros in 2005 and 2006. Mauresmo reached the quarter-finals in 2003 and 2004 and lost in the fourth round last year.

Also, Maria Sharapova reached the fourth round of the French Open for the fourth time in her career, coming back from 4-1 down in the second set to beat Alla Kudryavtseva 6-1, 6-4 despite a bothersome right shoulder.

The second-seeded Russian needed only 28 minutes to win the first set, breaking her opponent three times. But Sharapova was broken three consecutive times in the second set, before winning five straight games.

Sharapova, who lost in the fourth round last year and reached the quarter-finals at Roland Garros in 2004 and 2005, next faces No 14 Patty Schynder — and could also meet Safarova in the quarter-finals. Sharapova, who has 15 career titles and lost to Serena Williams in the final of the Australian Open, has yet to win a title this year.

Schnyder of Switzerland beat Karin Knapp of Italy 6-1, 4-6, 7-5. No 3 Svetlana Kuznetsova of Russia, a finalist last year, beat Dominika Cibulkova of Slovakia 6-2, 6-3. Also, No 7 Ana Ivanovic of Serbia advanced to the fourth round after beating Ioana Raluca Olaru of Romania 6-2, 6-0.